GLP-1 Injection Site Rotation: Complete 6-Zone Body Map to Prevent Lipodystrophy

Subcutaneous GLP-1 pens must be delivered into the adipose layer beneath the skin. Repeating the exact same spot causes lipohypertrophy (rubbery subcutaneous nodules) that impairs drug bioavailability.

The 6 FDA/EMA Approved Subcutaneous Zones

1. Left & Right Abdomen: At least 2 inches (5 cm) away from the navel.
2. Left & Right Front/Outer Thigh: Middle third of the thigh while seated.
3. Left & Right Back of Upper Arm: Outer posterior triceps area.